Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition
نویسندگان
چکیده
منابع مشابه
Human P2X7 receptor activation induces the rapid shedding of CXCL16.
Activation of the purinergic P2X7 receptor by extracellular ATP induces the shedding of cell-surface molecules including the low-affinity IgE receptor, CD23 from leukocytes. CD23 is a known substrate of a disintegrin and metalloprotease (ADAM)10. The aim of the current study was to determine if P2X7 activation induced the shedding of the chemokine CXCL16, an ADAM10 substrate. Using immunolabell...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2017
ISSN: 1759-4685
DOI: 10.1093/jmcb/mjx030